Coordinated human sleeping brainwaves map peripheral body glucose homeostasis
Cell/2023: Deep-sleep brain waves are linked to blood sugar control
- Coupled NREM sleep brainwaves predict superior next-day glucose control in two cohorts
- This sleep-glucose association is partially mediated by autonomic activity
- Sleep may regulate glycemic status selectively via insulin sensitivity
- NREM brainwaves thus offer a glycemic biomarker and a potential therapeutic target
Sleep and Blood Glucose Levels: “Over the past few decades, the overall average number of hours slept each night has apparently decreased. This decrease in sleep may have contributed to the increase in obesity and diabetes that occurred over the same stretch of time.”
“epidemiological evidences are indicating that chronic partial sleep loss may increase the risk of diabetes. Laboratory studies have shown that sleep restriction is associated with an increase in sympathetic nervous activity and a decrease in insulin sensitivity without adequate compensation in beta-cell function, resulting in an impact on glucose homeostasis and an elevated risk of diabetes.”
Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin
“Our results suggest that frequent insomnia symptoms cause higher HbA1c levels and, by implication, that insomnia has a causal role in type 2 diabetes. These findings could have important implications for developing and evaluating strategies that improve sleep habits to reduce hyperglycemia and prevent diabetes.”
Insomnia could play direct role in causing type 2 diabetes
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